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Sterile aqueous formulation based injectable cross-linked Hyaluronic acid and hydroxyapatite for Therapeutic use
专利权人:
ANTEIS S.A.
发明人:
申请号:
ARP130103636
公开号:
AR092934A1
申请日:
2013.10.08
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Aqueous formulation absorbable injectable sterile, Ready to use, used for Therapeutic purposes in the form of a viscoelastic gel Cohesive particles, including: (i) cross-linked Hyaluronic acid or its Salts,At a concentration of between 1% and 4% (MASS / Volume); Crosslinking made allows for a cross-linked Hyaluronic acid based gel of a Cohesive structure called hydroxyapatite and (ii) at a concentration of between 10% and 70% (MASS / Volume) is prese; hydroxyapatite NTA in the form of an average particle size less than or equal to 650 mm; the aqueous formulationSterile injection possesses viscoelastic properties such as Tand, at a frequency of 1 Hz is lower than or equal to 0.60. Claim 6: injectable sterile aqueous formulation according to any preceding claim, characterized by the fact that the formulation also includes one or more ceramic materials, such as tricalcium phosphate.Claim 8: injectable sterile aqueous formulation according to any preceding claim, characterized by the fact that the formulation also includes one or more anaesthetic. Claim: The injectable sterile aqueous formulation according to claim 1, characterized by the fact that the anesthetic Lidocaine hydrochloride.Claim 1: The injectable sterile aqueous formulation according to any preceding claim, characterized by the fact that the formulation also includes one or more antioxidants.Claim 13: injectable sterile aqueous formulation according to claim 1, characterized by the fact that the Polyols include sorbitol or mannitol, glycerol, Propylene Glycol.Claim 14: injectable sterile aqueous formulation according to any preceding claim, characterized by the fact that the formulation also includes one or more growth factors such as the family of bone morphogenetic proteins (BMPs) or the Transforming Growth Factor B (TGF BS).Claim: The Formula 15 aqueous injectable sterile under any of the preceding Claims, used in orthopaedic surgery, maxillofacial surgery, dental, ENT, urology, Gastroenterology, gyne
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