Systems and methods are provided that enable the magnetophoretic separation of magnetic particles using Dean flow in curved fluidic channels. In some example embodiments, a magnetic microparticle solution and a buffer solution are injected into a proximal region of a curved fluidic channel, and channel and fluidic parameters are selected to achieve solution exchange via Dean flow, such that the lateral positions of injected laminar fluid streams are inverted in a distal region of the channel. An applied magnetic field gradient is employed to retain the magnetic microparticles proximal to a channel side wall during the solution exchange process, such that magnetic microparticles are separated into the buffer solution. Various example device configurations are disclosed, including example configurations including one or more additional fluidic components for the further processing of separated magnetic particles.
