The present invention relates to a solid dispersion and a preparation method therefor. The solid dispersion contains a glucokinase activator, an isotopic label thereof, or a medicinal salt thereof and a polymer support. The present invention further relates to a solid dispersion composition containing the solid dispersion and an excipient. The present invention also relates to an oral preparation of the glucokinase activator, containing the solid dispersion or the solid dispersion composition. The present invention also relates to a tablet and a capsule of the glucokinase activator and a preparation method therefor. In addition, the present invention also relates to uses of the solid dispersion, the solid dispersion composition and the oral preparations comprising the tablet and the capsule, which can be used for treating and/or preventing selected diseases or medical conditions and especially one or more diseases selected from type I diabetes mellitus, type II diabetes mellitus, impaired glucose tolerance, impaired fasting glucose and hyperglycemia.本發明涉及固體分散體及其製備方法，其中，所述固體分散體包含葡萄糖激酶活化劑、其同位素標記物或其可藥用鹽和聚合物載體。本發明進一步涉及包含所述固體分散體和賦形劑的固體分散體組合物。本發明還涉及葡萄糖激酶活化劑的口服製劑，其包含所述固體分散體或固體分散體組合物。本發明還進一步涉及葡萄糖激酶活化劑的片劑和膠囊劑及它們的製備方法。另外，本發明還涉及固體分散體、固體分散體組合物和口服製劑包括片劑和膠囊劑的用途，其用於治療和/或預防所選疾病及醫學病症，尤其一種或多種選自I型糖尿病、II型糖尿病、葡萄糖耐量降低、空腹血糖異常以及高血糖症的疾病。
