Thomas Dyrmann Leser;Bénédicte Flambard;Thomas Gunnarsson;Jens Kildsgaard;Janni Wandahl Pedersen
发明人:
Thomas Dyrmann Leser,Thomas Gunnarsson,Jens Kildsgaard,Janni Wandahl Pedersen,Bénédicte Flambard
申请号：
US13256852
公开号：
US20120027737A1
申请日:
2010.03.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to the use of a composition comprising probiotic bacteria that regulate expression of key components involved in diet-induced insulin resistance for ameliorating or preventing diet-induced insulin resistance. The use of the probiotic strain and/or a fraction of said strain and/or metabolite of said strain for the manufacture of a medicament or a food or feed product to ameliorate diet-induced insulin resistance and help to obtain optimal body weight of a mammal is disclosed. Preferably, the composition comprises at least one probiotic Lactobacillus acidophilus strain and/or a fraction of said strain and/or metabolite of said strain for ameliorating or preventing diet-induced insulin resistance, said composition characterized by up-regulating expression of the ANGPTL4 gene encoding for FIAF in the intestine, down-regulating expression of the Elovl6 gene in the intestine as well as down-regulating expression of the SCD1 gene in skeletal muscles of a mammal, and wherein the probiotic strain is selected from the group of strains consisting of Lactobacillus acidophilus strain LA-5 (DSM13241).
