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Améliorations sur ou concernant des liposomes amphotères
专利权人:
Marina Biotech; Inc.
发明人:
申请号:
EP06254821.9
公开号:
EP1764091B1
申请日:
2006.09.15
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.
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中国工程科技知识中心
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