Compositions and methods for altering second messenger signaling

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专利权人:

Memorial Sloan Kettering Cancer Center;The Rockefeller University;Rutgers, The State University of New Jersey;University of Bonn

发明人:

Dinshaw Patel,Thomas Tuschl,Manuel Ascano, Jr.,Yang Wu,Yizhou Liu,Winfried Barchet,Gunther Hartmann,Thomas Zillinger,Roger Jones,Barbara L. Gaffney,Pu Gao

申请号：

US14787611

公开号：

US09840533B2

申请日:

2014.04.29

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof； methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions； methods of using the compounds as described herein for modulating cGAS and STING； and methods of designing or characterizing a cGAS modulator.

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