A wrist and thumb brace comprised of:a wrist brace portion for stabilizing a users wrist, the wrist portion having a first aperture adapted for a users right thumb when the brace is on a users right hand, and a second aperture adapted for a users left thumb when the brace is on a users left hand, the first and second apertures configured to facilitate ambidextrous use of the brace anda thumb brace portion for stabilizing a users thumb, the thumb brace portion removeably attachable to the wrist brace portion at a first location adjacent to the first aperture when the brace is on a users right hand, the thumb brace portion removeably attachable to the wrist brace portion at a second location adjacent to the second aperture when the brace is on a users left hand.