MOSHER, Gerold L.,WEDEL, Rebecca L.,JOHNSON, Karen T.,MACHATHA, Stephen G.,COWEE, Jane A.,CUSHING, Daniel J.
申请号：
AU2014200085
公开号：
AU2014200085A1
申请日:
2014.01.08
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2014200085A120140123.pdf#####H:\amft\Inten voyen\NRPortbl\DCC\AM\5928962_.DOC.7/01/2014 ABSTRACT The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic de gradation, thermal deg radation, an d photol ytic de gradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CDcontaining composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD.
