MOSHER, Gerold I.,WEDEL, Rebecca L.,JOHNSON, Karen T.,MACHATHA, Stephen G.,COWEE, Jane A.,CUSHING, Daniel J.
申请号：
AU2015255164
公开号：
AU2015255164B2
申请日:
2015.11.09
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2015255164B220170608.pdf#####ABSTRACT The present invention provides compositions containing clopidogrel, present as a free base or a. pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolvtic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CDcontaining composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered. perorally and excluding SAE-CD.
