The present invention provides a method for producing a porous tissue regeneration substrate, a method for producing an artificial blood vessel, and an artificial blood vessel in which the choice of solvent is wide and the bulk density and pore diameter of the porous substrate can be easily adjusted With the goal. The present invention is a porous tube-shaped artificial blood vessel made of a bioabsorbable material, and has a skin layer having a relatively small pore diameter in the innermost layer, and a porous material having a relatively large pore diameter around the skin layer. An artificial blood vessel having a stratified layer.本発明は、溶媒の選択肢が広く、容易に多孔質基材のかさ密度と孔径とを調整可能な多孔質組織再生基材の製造方法、人工血管の製造方法、及び、人工血管を提供することを目的とする。本発明は、生体吸収性材料からなる多孔質のチューブ状の人工血管であって、最内層に相対的に孔径が小さなスキン層を有し、該スキン層の周りに相対的に孔径が大きな多孔質層を有する人工血管である。
