您的位置: 首页 > 农业专利 > 详情页

PREVENTION OF TISSUE ISCHEMIA AND RELATED METHODS
专利权人:
The United States of America, as represented by the Secretary, Dept. of Health and Human Services;Washington University
发明人:
Jeffrey S. Isenberg,David D. Roberts,William A. Frazier
申请号:
US16443415
公开号:
US20200095306A1
申请日:
2019.06.17
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided herein are compositions for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing CD47 and/or blocking TSP1 and/or CD47 activity or interaction. Influencing the interaction of CD47-TSP1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function. Under conditions of decreased blood flow, for instance through injury or atherosclerosis, blocking TSP1-CD47 interaction allows blood vessels to dilate and increases blood flow, tissue perfusion and tissue survival.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充