The United States of America, as represented by the Secretary, Dept. of Health and Human Services;Washington University
发明人:
Jeffrey S. Isenberg,David D. Roberts,William A. Frazier
申请号：
US16443415
公开号：
US20200095306A1
申请日:
2019.06.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are compositions for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing CD47 and/or blocking TSP1 and/or CD47 activity or interaction. Influencing the interaction of CD47-TSP1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function. Under conditions of decreased blood flow, for instance through injury or atherosclerosis, blocking TSP1-CD47 interaction allows blood vessels to dilate and increases blood flow, tissue perfusion and tissue survival.
