The invention provides Dsg2-derived peptides for inhibiting EMT and/or vasculogenic mimicry and treating and/or preventing angiogenesis-related diseases. Also provided are pharmaceutical compositions comprising the peptide of the invention and methods of using the peptide of the invention in inhibiting EMT and/or vasculogenic mimicry, and treating and/or preventing angiogenesis-related diseases.本發明提供用於抑制EMT及/或血管生成擬態且治療及/或預防血管生成相關疾病之Dsg2衍生肽。亦提供包含本發明之肽之醫藥組合物及使用本發明之肽抑制EMT及/或血管生成擬態且治療及/或預防血管生成相關疾病之方法。