Use of a combination of sulfated glycosaminoglycan and hyaluronidase to improve the bioavailability of factor VIII

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专利权人:

ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー

发明人:

ザビーネ・ゾルナー,フーベルト・メッツナー

申请号：

JP2014536227

公开号：

JP6029674B2

申请日:

2012.10.18

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The present invention relates to pharmaceutical preparations comprising Factor VIII, a sulfated glycosaminoglycan and a hyaluronidase for the non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders. The invention further relates to the combined use of a Factor VIII, a sulfated glycosaminoglycan and a hyaluronidase for the treatment and prevention of bleeding disorders, and to a method for increasing the bioavailability after non-intravenous administration of Factor VIII by co-administration of a sulfated glycosaminoglycan and a hyaluronidase.

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中国工程科技知识中心

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http://www.ckcest.cn/home/