Pirrolo compounds [2,3-d] pyrimidine and its use for the treatment of various types of cancer through the Modulation of the activity of protein tyrosine kinase
The present application describes organic compounds that are useful for the treatment, Prevention,And / or alleviation of diseases； in particular are described pirrolo - pyrimidine compounds and their Derivatives that inhibit Protein Kinases.Organic Compounds are useful in the treatment of proliferative diseases.Claim 1: a compound of the formula (1) or a pharmaceutically acceptable Salt or solvate thereof, wherein: The dotted line indicates a double bond is cr u2075； or,Where r u2075 is Hydrogen or alkyl c u2081 u208b u2083； R u00b2 and r u00b3 are each independently selected from the group consisting of hydrogen, c u2081 u208b u2083 hydroxyl, alkyl, cycloalkyl c u2083 u208b u2088, heterociclilo,Aryl, heteroaryl substituted alkyl, cycloalkyl substituted c u2081 u208b u2083, c u2083 u208b u2088, heterociclilo substituted aryl substitutedAnd heteroaryl substituted； r u2074 is selected from the group consisting of C (H) ( u2082 ch u2082ch u2083), C (H) (ch u2082ch u2083) pH, ch u2082ch u2083 ciclopropilo Cyclopentyl, Cyclohexyl, or X is n or cr u00b9 u00b9,；And it's cr u00b9 u00b2； r u00b9 u00b9 is selected from the group consisting of hydrogen, halogen, alkoxy alkyl c u2081 u208b u2083, c u2081 u208b u2083 Noh, NS, c = C, c = noch u2083, H (o) C (o) c u2081 u208b u2083 alkyl, cycloalkyl, aryl, c u2083 u208b u2088, heterociclilo,Heteroaryl substituted alkyl, cycloalkyl substituted c u2081 u208b u2083, c u2083 u208b u2088 heterociclilo substituted aryl, heteroaryl substituted, replaced, bnr u00b9 u00b3r u00b9 u2074 bor u00b9 u00b3, -, -, - r u00b9 u00b3 BC (OR), (OR) - BC or u00b9 u00b3,- nr u00b9 u00b3r u00b9 u2074 BC (OR), where B is a Link, c u2081 u208b u2083 branched alkyl or alkyl c u2081 u208b u2083； where r u00b9 u00b3 and r u00b9 u2074 are each independently selected from the group consisting of hydrogen, alkyl c u2081 u208b u2083,C u2083 u208b u2088 heterociclilo, cycloalkyl, aryl, heteroaryl substituted alkyl, cycloalkyl substituted, heterociclilo substitut
