Butler, David,Iwamoto, Naoki,Meena, Meena,Svrzikapa, Nenad,Verdine, Gregory L.,Zlatev, Ivan
申请号：
AU2018205183
公开号：
AU2018205183A1
申请日:
2018.07.13
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018205183A120180802.pdf#####Abstract The present invention relates to chirally controlled oligonucleotides, chirally controlled 5 oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present 10 invention provides chirally controlled oligonulcleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions. C: STANDARD PS DNA NOT STEMOSPEGFIC -219 ISEROs A SINGLE ISOMER nS D-A FULL Pp4I~j~E * I C~f rP； I r . 1 II I I' bC' 2 i 4 1 Et 1 h 1 Ij HOkO 3- &R.: 1O 12 14,00f11.% 181) 2V1{ 22 .2 2Eo® 2&c{) FIG. 1 10464117_1 (GHMatters) P100197.AU.1
