您的位置: 首页 > 农业专利 > 详情页

AGONISTES DU RECEPTEUR DU TYPE GUANYLATE CYCLASE SERVANT AU TRAITEMENT DE L'INFLAMMATION TISSULAIRE ET DE LA CARCINOGENESE
专利权人:
INC.;SYNERGY PHARMACEUTICALS
发明人:
SHAILUBHAI, KUNWAR,NIKIFOROVICH, GREGORY,JACOB, GARY S.
申请号:
CA2441970
公开号:
CA2441970C
申请日:
2002.03.28
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
A method of treatment of inflamed, pre-cancerous or cancerous tissue or polypsin a mammalian subject is disclosed. The treatment involves administration ofa composition of at least one peptide agonist of a guanylate cyclase receptorand/or other small molecules that enhance intracellular production of cGMP.The at least one peptide agonist of a guanylate cyclase receptor may beadministered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The inhibitor may be a small molecule, peptide,protein or other compound that inhibits the degradation of cGMP. Withoutrequiring a particular mechanism of action, this treatment may restore ahealthy balance between proliferation and apoptosis in the subject'spopulation of epithelial cells, and also suppress carcinogenesis. Thus, themethod may be used to treat, <;i>;inter alia<;i/>;, inflammation, includinggastrointestinal inflammatory disorders, general organ inflammation andasthma, and carcinogenesis of the lung, gastrointestinal tract, bladder,testis, prostate and pancreas, or polyps.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充