SHAILUBHAI, KUNWAR,NIKIFOROVICH, GREGORY,JACOB, GARY S.
申请号：
CA2441970
公开号：
CA2441970C
申请日:
2002.03.28
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
A method of treatment of inflamed, pre-cancerous or cancerous tissue or polypsin a mammalian subject is disclosed. The treatment involves administration ofa composition of at least one peptide agonist of a guanylate cyclase receptorand/or other small molecules that enhance intracellular production of cGMP.The at least one peptide agonist of a guanylate cyclase receptor may beadministered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The inhibitor may be a small molecule, peptide,protein or other compound that inhibits the degradation of cGMP. Withoutrequiring a particular mechanism of action, this treatment may restore ahealthy balance between proliferation and apoptosis in the subject'spopulation of epithelial cells, and also suppress carcinogenesis. Thus, themethod may be used to treat, <；i>；inter alia<；i/>；, inflammation, includinggastrointestinal inflammatory disorders, general organ inflammation andasthma, and carcinogenesis of the lung, gastrointestinal tract, bladder,testis, prostate and pancreas, or polyps.
