Compounds for use in methods for enhancing stable cavitation during sonothrombolysis are provided. Methods and systems are also provided. The method for enhancing stable cavitation during sonothrombolysis comprises administering a nucleating agent and a thrombolytic agent to a treatment zone of a patient. The method further comprises providing, substantially throughout the treatment zone of the patient, a determined level of ultrasonic energy produced by a source transducer. The determined level of ultrasonic energy comprises a fundamental ultrasonic frequency, and is provided in intervals separated by rest periods. Substantially no ultrasonic energy is provided during the rest periods, such that the intervals of the determined level of ultrasonic energy enhance stable cavitation during sonothrombolysis.
