Christy K. Holland;Saurabh Datta;Kevin Haworth;T. Douglas Mast;Kathryn Elizabeth Hitchcock;Nikolas Ivancevich
发明人:
Christy K. Holland,Saurabh Datta,T. Douglas Mast,Nikolas Ivancevich,Kathryn Elizabeth Hitchcock,Kevin Haworth
申请号：
US13257657
公开号：
US20120130288A1
申请日:
2010.03.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes providing a determined level of ultrasonic energy and detecting a scattered level of ultrasonic energy. The system for inducing and passively detecting stable cavitation includes a dual-element annular transducer array configured to provide a fundamental ultrasonic frequency and to detect an ultrasonic frequency that is a derivative of the fundamental frequency. The method of enhancing stable cavitation includes administering a nucleating agent and a thrombolytic agent to a treatment zone, providing a determined level of ultrasonic energy, and detecting a scattered level of ultrasonic energy.
