TAMAI, KATSUTO,YAMAZAKI, TAKEHIKO,KANEZAKI, TSUTOMU,SAKURAI, SHIGERU,NOGUCHI, YUKIKO,ENDO, MAYUMI,HAMABUCHI, NATSUMI,NAITO, KANA
申请号：
CA2834255
公开号：
CA2834255A1
申请日:
2012.04.03
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
[Problem] To provide a therapeutic agent which can promote the recruitment of PDGFRa-positive cells such as bone marrow-derived mesenchymal stem cells in blood and the accumulation of the PDGFRa-positive cells in damaged tissues, both of which are caused by the stimulation of the PDGFa-positive cells, thereby inducing the regeneration of tissues in vivo. [Solution] Multiple peptides are synthesized, and it is tried to assess the migration activity of each of the peptides. As a result, multiple peptides having a migration activity on a PDGFRa-positive bone marrow-derived mesenchymal stem cell strain (MSC-1) are successfully identified. Further, it is confirmed that the identified peptides also have a migration activity on skin fibroblasts that are PDGFRa-positive cells and the like.
