Caroline Jane BARELLE,William James Jonathan FINLAY,Alfredo DARMAN-IN-SHEEHAN
申请号：
US14785975
公开号：
US20160068600A1
申请日:
2014.04.23
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides ICOSL specific antigen binding molecules which are isolated from immunized and synthetic Elasmobranchii derived libraries. In particular, the present invention relates to shark Variable New Antigen Receptor (VNAR) domains that specifically bind and neutralize the activity of human Induced Co-Stimulatory Ligand (ICOSL). The neutralizing VNAR domains are isolated from two independent sources an immunized nurse shark library and a synthetic spiny dogfish framework fusion library. The molecules may be formulated as pharmaceutical compositions and used in medicine.
