A sanitary clamp for connection to a pair of barb connectors each having one end terminating at a funnel shaped portion is described herein. The sanitary clamp includes a first member having a first semi-circular center portion disposed between a first end and a second end. A second member has a second semi-circular center portion disposed between a first end and a second end. Said first ends of the first and second members are configured to pivotally connect to each other, and said second ends of the first and second members include a locking mechanism for selectively locking the second ends of the first and second members in engagement.