FEDERAL STATE AUTONOMOUS EDUCATIONAL INSTITUTION OF HIGHER PROFESSIONAL EDUCATION "BELGOROD STATE NATIONAL RESEARCH UNIVERSITY"
发明人:
TRUBITSYN, Mihail Alexandrovich,ТРУБИЦЫН, Михаил Александрович,GABRUK, Natalia Georgievna,ГАБРУК, Наталья Георгиевна,DOAN, Van Dat,ДОАН, Ван Дат,LE, Van Tkhuan,ЛЕ, Ван Тхуан
申请号：
RURU2013/000781
公开号：
WO2014/014392A3
申请日:
2013.09.06
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The method for producing single-phase nanocrystalline silicon-substituted hydroxyapatite, which can be used for producing medical materials which stimulate the regeneration of defects in bone tissue, including in dentistry, relates to technology for producing inorganic materials. The synthesis of silicon-containing hydroxyapatite having a degree of silicon substitution x=1-2 and a molar ratio of Ca/(P+Si) approximating 1.67, is carried out by precipitation from an aqueous solution of reagents containing orthophosphoric acid, calcium hydroxide and tetraethyl orthosilicate at a pH of no less than 9 and with a molar ratio of Ca/P of between 2.0 and 2.5. A composition is prepared of 0.08-0.16% aqueous solution of calcium hydroxide and tetraethyl orthosilicate. A solution of orthophosphoric acid with a 10-20% concentration is added at a rate of 0.2-0.8 ml/min per liter of aqueous solution of the calcium hydroxide/tetraethyl orthosilicate composition. The above is left to settle in order to complete the process of phase formation, and the precipitate is separated off and dried. Heat treatment is conducted at a temperature no lower than 300°C but no higher than 400°C.Linvention concerne un procédé de production dun hydroxyapatite substitué par silicium nanocristallin qui peut sutiliser dans la préparation de matériaux médicaux stimulant la réhabilitation des tissus osseux lésés, notamment en stomatologie, et concerne le domaine de la technologie de production de matériaux inorganiques. La synthèse dun hydroxyapatite substitué par silicium avec un degré de substitution par silicium x=1-2 et un rapport molaire Ca/(P+Si) proche de 1,67 est effectuée par sédimentation à partir dune solution aqueuse de réactifs comprenant lacide orthophosphorique, lhydroxyde de calcium et lorthosilicate de tétraéthyle avec un pH de pas moins 9 et un rapport molaire Ca/P compris entre 2,0 et 2,5. On prépare une composition à base dune solution aqueuse 0,08-0,16% dhydroxyde de calcium et dorthosi
