LUO, YUEH HSIA,罗月霞,羅月霞,LIN, SHU YI,林淑宜,林淑宜,LIN, PINPIN,林嫔嫔,林嬪嬪
申请号：
TW105106483
公开号：
TW201731517A
申请日:
2016.03.03
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
An endotoxin nanovesicle for enhancing type 1 T helper cell-induced immunological responses is disclosed. The endotoxin nanovesicle comprises: (a) lipopolysaccharide molecules, assembled into a vesicle with a wall surrounding an inner space and (b) hydrophilic gold nanodots, localized in the wall of the vesicle. Methods of suppressing formation of cubosomes and/or hexosomes in lipopolysaccharide aggregation or assembly, and methods of preparing a lipopolysaccharide adjuvant are also disclosed. Also disclosed are compositions comprising an endotoxin aggregate or an endotoxin nanovesicle and optionally an immunogenic antigen.本發明揭露一種內毒素奈米微粒,係用於增強第一型輔助性T細胞誘導之免疫反應。該內毒素奈米微粒包含:(a)脂多醣分子,係聚集為一具有包圍一內部空間之壁的微粒;及(b)親水性金奈米點,係位在該微粒之壁中。本發明亦揭露在脂多醣聚合或聚集時抑制立方體及/或六方體形成的方法,以及製備一脂多醣佐劑的方法。本發明亦揭露組成物,包含一內毒素聚集體或一內毒素奈米微粒,以及一選擇性地免疫性產生抗原。
