FIELD: medicine.SUBSTANCE: invention relates to medicine and is intended for the differential diagnosis of high duodenogastroesophageal, acid, weak acid and weak alkaline refluxes. Collect unstimulated mixed saliva of the patient, determine the total and direct bilirubin, with the values of total bilirubin in the saliva 2.36–2.91 mcmol/l and direct bilirubin 1.39–2.31 mcmol/l determine the absence of high gastroesophageal refluxes; with the values of total bilirubin of 2.92–3.18 mcmol/l and direct bilirubin of 2.45–2.64 mcmol/l – the weak acid nature of refluxate; total bilirubin 3.19–3.60 mcmol/l and direct bilirubin 2.32–2.44 mcmol/l – the acid nature of the refluxate; total bilirubin 3.61 mcmol/l and more and direct bilirubin 2.65 mcmol/l and more – weak alkaline nature of refluxate.EFFECT: method allows to increase the efficiency of differential diagnosis of GERD.1 cl, 3 ex