Provided herein is a method of treating, preventing, or alleviating one or more symptoms of cancer in a subject, comprising administering to the subject a therapeutically effective amount of: (i) ascorbic acid, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof； or a pharmaceutically acceptable salt, solvate, or hydrate thereof； (ii) a quinone compound, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof； or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof； and (iii) a sodium glucose cotransporter inhibitor, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof； or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.
