白細胞介素１５蛋白質複合物及其用途农业专利-农业专业知识服务系统

专利权人:: SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.;JIANGSU HENGRUI MEDICINE CO., LTD.

发明人:: QU, XIANGDONG,屈向东,屈向東,YE, XIN,叶鑫,葉鑫,HU, QIYUE,胡齐悦,胡齊悅,CUI, DONGBING,崔东冰,崔東冰,TAO, WEIKANG,陶维康,陶維康,ZHANG, LIANSHAN,张连山,張連山,SUN, PIAOYANG,孙飘扬,孫飄揚

摘要：: The present invention relates to an IL-15 protein complex and pharmaceutical uses thereof. The IL-15 protein complex comprises soluble protein (I) and soluble protein (Π), wherein the said soluble protein (I) was IL-15 or variants thereof； wherein the said soluble protein (Π) is IL-15 R α or variants thereof. Specifically, there are one or more amino acid positions mutated to Cys correspondingly on the soluble fusion protein (I) or the soluble fusion protein (Π), and the corresponding Cys mutation can conjugate to form disulfide bonds. The IL-15 protein complex of the present invention is used in the treatment of tumor therapy.本發明涉及一種白細胞介素15蛋白質複合物及其用途。該白細胞介素15(IL-15)蛋白質複合物由可溶性融合蛋白(I)和可溶性融合蛋白(Π)組成；其中可溶性融合蛋白(I)為IL-15多肽或其功能性片段；可溶性融合蛋白(Π)為IL-15R α多肽或其功能性片段；其中，可溶性融合蛋白(I)或可溶性融合蛋白(Π)上具有一個或多個胺基酸位點突變成Cys，與對應的可溶性融合蛋白(Π)或可溶性融合蛋白(I)胺基酸位點上突變成的Cys配對形成二硫鍵。本發明提供的IL-15蛋白質複合物可用於腫瘤治療。