GLICK, Gary D.,HURD, Alexander R.,TAYLOR, Clarke B.,VANHUIS, Chad A.,GLICK GARY D,GLICK, GARY D.,HURD ALEXANDER R,HURD, ALEXANDER R.,TAYLOR CLARKE B,TAYLOR, CLARKE B.,VANHUIS CHAD A,VANHUIS, CHAD A.
申请号：
ES11846595
公开号：
ES2639439T3
申请日:
2011.12.08
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound represented by Formula I: ** Formula ** including all stereoisomers, geometric isomers and tautomers； or a pharmaceutically acceptable salt or solvate of any of the foregoing； where: A1 is phenylene or a six-membered heteroarylene； ** Formula ** R1 independently represents each time halogen, haloalkyl, alkyl, cycloalkyl, heterocycloalkyl, hydroxyl, C1-C6 alkoxy, cyano, -CO2R8, -C (O ) R9, -S (O) R9, -SO2R9, -SO2N (R10) (R11), -C (O) N (R10) (R11), -N (R10) (R11) or -N (R8) C (O) (R9)； R2 is hydrogen or alkyl； R3 is aryl, aralkyl, cycloalkyl, - (C (R8) 2) m-cycloalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, - (C (R8) 2) mheterocycloalkyl, alkyl, haloalkyl, hydroxyalkyl, - (C (R8) 2) m-alkoxy, - (C (R8) 2) mO- (C (R8) 2) m-alkoxy or - (C (R8) 2) m-CN, wherein said aryl, aralkyl, cycloalkyl, heteroaryl, heteroaralkyl and heterocycloalkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, hydroxyalkyl, C1-C6 alkoxy, cyano and C1-C6-CO2R8 alkylene ； R4 is hydrogen, alkyl or -C (O) R9； or R3 and R4 are considered together with the nitrogen atom to which they are attached to form a 3- to 7-membered heterocyclic ring optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl and C1-C6 alkoxy； R5 is hydrogen or alkyl； R6 is haloalkyl； R7 is hydrogen, halogen, alkyl or haloalkyl； R8 independently represents each time hydrogen, alkyl or cycloalkyl appears； or, when R8 appears twice bound to the same carbon atom, both occurrences are considered together with said carbon atom to form a saturated carbocyclic ring； R9 represents independently each time alkyl or cycloalkyl appears； R10 and R11 each independently represent each time hydrogen, alkyl or cycloalkyl appear； or R10 and R11 are considered in conjunction with the nitrogen atom to which they are attached to
