The purpose of the present invention is to provide: a pluripotent stem cell migration promoter comprising an extract from a tissue having inflammation induced by the inoculation of a vaccinia virus and others. In the present invention it is demonstrated that an extract from a tissue having inflammation induced by the inoculation of a vaccinia virus can promote the migration of Muse cells. Thus the present invention provides: a pluripotent stem cell migration promoter for various diseases on which the migration of pluripotent stem cells is expected to be effective and others.