PROBLEM TO BE SOLVED: To provide an anti-cadherin antibody having a high internalization capacity and provide an anti-cadherin antibody-drug conjugate that effectively kills cadherin-expressing cancer cells with the use of such antibody.SOLUTION: The present invention provides an anti-cadherin antibody which recognizes a cadherin domain 1 (EC1) of cadherin and exhibits a high internalization capacity.SELECTED DRAWING: None【課題】高い内在化能を有する抗カドヘリン抗体を提供し、さらにこれを用いてカドヘリンを発現する癌細胞を効率的に殺傷する抗カドヘリン抗体薬剤コンジュゲートを提供すること。【解決手段】カドヘリンのカドヘリンドメイン1(EC1)を認識し、かつ高い内在化能を示す抗カドヘリン抗体。【選択図】なし