A medical procedure mat for supporting a patient. A mat having a cushioned substrate and one or more physiological monitoring lines, the physiological monitoring lines having guided portions along the outer edge of the cushioned substrate, and flexible portions operatively coupled to the guided portions, the flexible portions being adapted to extend toward the patient. A draping system for use during medical procedures, including a top and/or bottom drape. A bottom drape including an absorbent material and/or a privacy shield. A top drape including a workbench surface. A mat and draping system in which a bottom and top drape mate to each other and/or to the mat. A draping system providing openings or holes to allow passage of one or more physiological monitoring lines when used in conjunction with the mat.