BH4 STABILIZED PEPTIDES AND USES THEREOF

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专利权人:

DANA-FARBER CANCER INSTITUTE; INC.

发明人:

WALENSKY, LOREN D.,STEWART, MICHELLE L.,BARCLAY, LAUREN

申请号：

CA2906775

公开号：

CA2906775A1

申请日:

2014.03.14

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

Provided herein are polypeptides containing stabilized BH4 domains of BCL-2 family proteins that are capable of binding and/or inactivating and/or modulating BAX protein, and/or its close homologues BAK and BOK, and/or other physiological BH4 targets. Also provided are compositions containing these polypeptides and methods of treating cytotoxic diseases that include administering to a subject one of the polypeptides.

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