Loren D. Walensky,Michelle L. Stewart,Lauren Barclay
申请号：
US14777391
公开号：
US10106590B2
申请日:
2014.03.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are polypeptides containing stabilized BH4 domains of BCL-2 family proteins that are capable of binding and/or inactivating and/or modulating BAX protein, and/or its close homologs BAK and BOK, and/or other physiological BH4 targets. Also provided are compositions containing these polypeptides and methods of treating cytotoxic diseases that include administering to a subject one of the polypeptides.
