Theodore Mark Kamenecka,Patrick R. Griffin,Youseung Shin,Yuanjun He,Anne-Laure Blayo,Brent R. Lyda,Marcel Koenig,Naresh Kumar,Thomas Burris
申请号：
US14118116
公开号：
US20140187554A1
申请日:
2012.05.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides small molecule modulators of retinoic acid receptor-related orphan receptors such as RORα, RORβ, or RORγ. Compounds of the invention can be effective modulators at concentrations ineffective to act on LXR receptors, or on other nuclear receptors, or other biological targets. Methods of modulation the RORs and methods of treating metabolic disorders, immune disorders, cancer, and CNS disorders wherein modulation of an ROR is medically indicated are also provided.
