ДИМАРЧИ Ричард Д. (US),ЯН Бинь (US),ФАЙНЭН Брайан (US)
申请号：
RU2012153755/10
公开号：
RU2012153755A
申请日:
2011.05.10
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A compound comprising the structure QLY where Q is a glucagon superfamily peptide Y represents NHR ligand which activates a nuclear hormone receptor ECpriblizitelno 1 uM or less and has a molecular weight up to about 1000 daltons and L is a linking group or svyaz.2. A compound according to claim 1, wherein Q has at least 0.1% of the activity of native GLP-1 relative to GLP-1 receptor, at least 0.1% of the activity relative to native glucagon glucagon receptor, or at least 0.1% of the activity of native GIP relatively GIP receptor or kombinatsiey.3. A compound according to claim 1, wherein Q is ECotnositelno GLP-1 receptor in the range of 10-fold relative magnitude ECY nuclear hormone receptor, glucagon receptor ECotnositelno within 10-fold relative magnitude ECY nuclear hormone receptor or ECotnositelno GIP receptor within 10 times the value of ECY on nuclear hormone retseptora.4. The compound of claim 1 wherein Y represents NHR ligand that acts on nuclear hormone receptor type I or type II.5. A compound according to claim 4, wherein Y represents NHR ligand which affects the nuclear hormone receptor is selected from the group consisting of estrogen receptor, glucocorticoid receptor, mineralocorticoid receptor, progesterone receptor, androgen receptor, thyroid hormone receptor, retinoic acid receptor, the receptor peroxisome proliferator-activated, liver X receptor farnezoidnogo X receptor, a receptor vitamin D, RAR-related receptor and orfanovogo pregna
