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AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND USE THEREOF AS PHARMACEUTICAL AGENTS
专利权人:
SANOFI
发明人:
RUF Sven (DE),РУФ Свен (DE),SADOVSKI Torsten (DE),САДОВСКИ Торстен (DE),KHORSTIK Georg (DE),ХОРСТИК Георг (DE),SHROJDER KHerman (DE),ШРОЙДЕР Херман (DE),BUNING Kristian (DE),БУНИНГ Кристиан (DE),OLPP,RUF Sven,РУФ Свен,SADOVSKI Torsten,САДОВСКИ Торстен,KHORSTIK Georg,ХОРСТИК Георг,SHROJDER KHerman,ШРОЙДЕР Херман,BUNING Kristian,БУНИНГ Кристиан,OLPP Tomas,ОЛЬПП Томас,VIRT Klaus,ВИРТ Клаус
申请号:
RU2013139352/04
公开号:
RU0002605600C2
申请日:
2012.01.26
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula I in form of any of its stereoisomeric forms, or its physiologically acceptable salt, where A denotes C(R1); D denotes N(R2); E denotes N; G denotes R71-O-C(O)-; R1 is selected from a group consisting of hydrogen and NC-; R2 denotes Ar-CsH2s-, where s denotes an integer 0 or R2 and R11 together denote -C(R18)=C(R19)-; R10 is selected from a group consisting of R11, R12-N(R13)-C(O)- and R14-C(O)- and (C1-C4)-alkyl-S(O)m-; R11 is selected from a group, consisting of hydrogen and R14 or R10 and11 form Het2; R12 and R13 are independently selected from a group, consisting of hydrogen and Ar; R30 is selected from a group, consisting of R31, (C3-C7)-cycloalkyl, R32-CuH2u-, where u denotes an integer selected from a group consisting of 0, 2 and 3; R40 is selected from a group consisting of hydrogen and (C1-C-4)-alkyl; R50 denotes hydrogen; R60 denotes hydrogen or R30 and R50 together denote (CH2)z, optionally substituted with one or more identical or different (C1-C4)-alkyl substitutes, where z denotes an integer selected from a group consisting of 3, 4 and 5; R71 denotes hydrogen; Ar, independently from each other group Ar, is selected from a group consisting of phenyl and aromatic 5-member or 6-member monocyclic heterocycle, which comprises one cyclic heteroatom selected from a group, consisting of nitrogen, oxygen, and is bonded to other part of molecules through a cyclic carbon atom, where phenyl is optionally substituted with one or more identical or different substitutes, selected from a group consisting of halogen, (C1-C6)-alkyl; Het2 denotes a saturated 5-6-member monocyclic heterocycle, which includes cyclic nitrogen atom, through which Het2 is bonded to other part of molecule, and optionally one additional cyclic heteroatom, selected from sulphur, optionally substituted with one or more substitutes, selected from oxo; m independently from each other m denotes 2. Invention also relates to a meth
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