RAVI DHAMJEWAR,CH PRAKASH RAO,NAGARAJU SANGA,NAGAKRISHNA PRASAD KUMBHAM
申请号：
IN6846/CHE/2015
公开号：
IN2015CH06846A
申请日:
2015.12.07
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
ABSTRACT: The present invention relates to a process synthetic process for preparing the side-chain precursor l- (mercaptomethyl)cyclopropancacctic acid, Which is useful in the synthesis of leukotriene receptor antagonist such as Montelukast and salts thereof. Preferably the present invention relates to a process for the prepartion of 1- (bromomethyl) Cyclopropane-acetonitrile starting from 1- (hydroxymethyl)cyclopropaneacetonitrile. Preferably, the present invention relates to avoiding the use of toxic solvent such as DMF and additional component such asr sodium iodide in the preparation ofl-(hydroxymethyl)cyclopropaneacetonitrile. Preferably, the present invention relates avoding the use of reagents PBr3 or Ph3P/Br2in the preparation of l-(bromomethyl) Cyclopropane-acetonitrile.
