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NOVEL COMPOUND AND ANTIVIRAL AGENT CONTAINING SAME AS ACTIVE INGREDIENT
专利权人:
NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
发明人:
Hiroshi SHIRASAWA,Takayoshi ARAI,Yutaka TAMURA,Kengo SAITO,Akiko SUGANAMI,Yoshifumi OHNO,Akira YANAGISAWA,Shoji MATSUMOTO,Tetsuhiro NEMOTO,Ouji WATANABE
申请号:
US15539846
公开号:
US20170368015A1
申请日:
2015.12.25
申请国别(地区):
US
年份:
2017
代理人:
摘要:
An object of the invention is to provide a compound that can be utilized as an antiviral agent, in particular as an anti-RNA viral agent, and especially as an anti-RS viral agent. The invention provides a compound indicated by Formula (1), wherein R1 each independently represent hydrogen, halogen, hydroxyl, amino, carboxyl, C1-C6 alkyl, C1-C6 alkoxyl, C1-C6 halogenoalkyl, C1-C6 alkoxycarbonyl, C1-C6 alkylamino, C2-C5 alkenyl, C3-C6 cycloalkyl, or optionally substituted aryl; R2 each independently represent hydrogen, C1-C6 alkyl, C1-C6 halogenoalkyl, C2-C5 alkenyl, C3-C6 cycloalkyl, optionally substituted aryl or heterocyclic group; and one or more R1 may be present in the same ring, an isomer thereof, a pharmaceutically acceptable salt thereof, or a mixture of these. The compounds provided by the invention are useful as drugs for the prevention or treatment of infectious diseases by virus, especially RS virus, and in particular infectious diseases in the lower airways (e.g., bronchiolitis, pneumonia, etc.).
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