600459 Disclosed herein are compounds of formula (I), wherein the variables are defined in the specification, in vitro methods for the detection of amyloids and the use in the treatment of diseases related to amyloids including Alzheimer&rsquos disease and other related amyloid-based neurodegenerative diseases. Specific embodiments of the compounds include the following: (E)-2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethyI-2-cyano-3-(2-(piperidin-1-yl)napthalen-6-yl) acrylate, and (E)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyI-2-cyano-3-(2-(piperidin-1-yl)naphthalene-6-yl) acrylate.
