PROBLEM TO BE SOLVED: To provide a SIRT-1 gene expression increasing agent and a cell cycle normalizing agent. SOLUTION: The SIRT-1 gene expression increasing agent and the cell cycle normalizing agent are characterized by containing an ethanol extract of moringa leaves substantially free of chlorophyll. [Selection diagram] Fig. 1【課題】SIRT-1遺伝子発現増加剤及び細胞周期正常化剤を提供すること。【解決手段】クロロフィルを実質的に含まないモリンガ葉のエタノール抽出物を含むことを特徴とするSIRT-1遺伝子発現増加剤及び細胞周期正常化剤。【選択図】図1