GALILI URI,PICKFORD CHRISTOPHER,GRIFFITHS GRAHAM JOHN CHARLES
申请号：
IN201627041152
公开号：
IN201627041152A
申请日:
2016.12.01
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The invention relates to pharmaceutical compositions comprising a Gal BOEL for use in treating patients with tumours. The invention also relates to methods of treating tumours using said compositions. The invention discloses that following intratumoural injection of a Gal BOEL binding of the natural anti Gal antibody to de novo expressed tumoural a Gal epitopes induces inflammation resulting in an anti Gal antibody mediated opsonization of tumour cells and their uptake by antigen presenting cells. These antigen presenting cells migrate to draining lymph nodes and activate tumour specific T cells thereby converting the treated tumour lesions into in situ autologous tumour vaccines. This therapy can be applied to patients with multiple lesions and in neo adjuvant therapy to patients before tumour resection. In addition to the regression and/or destruction of the treated tumour such a vaccine will help in the immune mediated destruction of micrometastases that are not detectable during the removal of the treated tumour. The invention further teaches the enhancement of anti tumour a Gal BOEL treatment by the use of antibodies that inhibit the activity of immunological checkpoints molecules.
