The purpose of the present invention is to provide an agent for promoting tau protein production containing a natural substance as the active ingredient, a therapeutic or prophylactic drug for disease caused by tau protein deficiency, and a therapeutic or prophylactic food product composition for disease caused by tau protein deficiency. Provided are an agent for promoting tau protein production, a therapeutic or prophylactic agent for disease caused by tau protein deficiency, and a therapeutic or prophylactic food product composition for disease caused by tau protein deficiency, containing dried worm powder, ground worm material, and/or worm extract as the active ingredient. The disease caused by tau protein deficiency is preferably Alzheimer's disease.提供含有天然物作為有效成分之Tau蛋白產生促進劑、起因於缺乏Tau蛋白之疾病的治療藥‧預防藥、起因於缺乏Tau蛋白之疾病的治療用‧預防用食品組成物。係含有蚯蚓之乾燥粉末、磨碎物及/或萃取物作為有效成分之Tau蛋白產生促進劑、起因於缺乏Tau蛋白之疾病的治療藥‧預防藥、起因於缺乏Tau蛋白之疾病的治療用‧預防用食品組成物。前述起因於缺乏Tau蛋白之疾病以阿茲海默症較佳。
