Ä1H-PYRAZOLOÄ3,4-DÜPYRIMIDIN-4-YLÜ-PIPERIDINE OR PIPERAZINE COMPOUNDS AS SERIN THREONINE KINAS MODULATORS (P70S6K, ATK1 AND ATK2) FOR THE TREATMENT OF IMMUNOLOGICAL, INFUSIBLE AND PROLIFERATIVE DISEASES

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专利权人:

EXELIXIS; INC.

发明人:

RICE, KENNETH,CO, ERICK,KIM, MOON,BANNEN, LYNN,BUSSENIUS, JOERG,LE, DONNA,TSUHAKO, AMY,NUSS, JOHN,WANG, YONG,XU, WEI,KLEIN, RHETT

申请号：

AT05855490

公开号：

AT543821T

申请日:

2005.12.27

申请国别(地区):

AT

年份:

2012

代理人:

摘要：

The invention provides compounds of formula (I) and methods for inhibition of kinases, more specifically p70S6 kinases, and more preferably p70S6, Akt-1 and Akt-2 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/