Jeff Chen;Grace Mann;Craig Stacy Takeuchi;Lisa Esther Dalrymple;Tai Phat Huynh;Timothy Patrick Forsyth;James William Leahy;Brian Hugh Ridgway;Larry W. Mann;Sergey Epshteyn;Joan C. Sangalang
发明人:
Jeff Chen,Lisa Esther Dalrymple,Sergey Epshteyn,Timothy Patrick Forsyth,Tai Phat Huynh,James William Leahy,Brian Hugh Ridgway,Grace Mann,Larry W. Mann,Craig Stacy Takeuchi,Joan C. Sangalang
申请号：
US10552424
公开号：
US08178570B2
申请日:
2004.04.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
