Hashim A. Ahmed,Susanne Page,Navnit Hargovindas Shah
申请号：
US13787870
公开号：
US08852634B2
申请日:
2013.03.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to a process for preparing a pharmaceutical tablet composition which comprises an active pharmaceutical ingredient of formula Iwherein the definitions are described in claim 1, or pharmaceutically acceptable acid addition salts thereof and a water soluble poloxamer in which the compound of formula I and the water soluble poloxamer are processed by hot melt extrusion, and then the hot melt extrudate is mixed with other ingredients to form a tablet, that is optionally coated with a composition comprising an immediate release film coating system and purified water. The invention also relates to such pharmaceutical compositions and hot melt extrudates.
