GANGADHARMATH, UMESH B.,KOLB, HARTMUTH C.,SCOTT, PETER J.H.,WALSH, JOSEPH C.,ZHANG, WEI,SZARDENINGS, ANNA KATRIN,SINHA, ANJANA,CHEN, GANG,WANG, ERIC,MOCHARLA, VANI P.,YU, CHUL,LIU, CHANGHUI,CASHION, D
申请号：
CA2756137
公开号：
CA2756137C
申请日:
2010.03.23
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Imaging agents of formula (I) and methods for detecting neurological disorderscomprising administering ti a patientin need compounds of formula (I) capable of binding to tau proteins and .beta.-amyloid peptides are presented herein. The inventionalso relates to methods of imaging A.beta. and tau aggregates comprisingintroducing a detectable quantity of pharmaceutical formulationcomprising a radiolabeled compound of formula (I) and detecting the labeledcompound associated with amyloid depositsand/or tau proteins in a patient. These methods and compositions enablepreclinical diagnosis and monitoring progressionof AD and other neurological disoders.
