ALEXANDRE URBANO,CARLA FABIANA SOUZA GUAZELLI,ISABELA SALOMÃO LUDWIG,LAISA GIORDANI VICENTE,MARCELA MARIA BARACAT,RUBIA CASAGRANDE,SANDRA REGINA GEORGETTI,VICTOR FATTORI,WALDICEU APARECIDO VERRI JUNIO
申请号：
BR102018014019
公开号：
BR102018014019A2
申请日:
2018.07.10
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
a composition comprising micro-encapsulated trans-chalcona for modified release in the gastrointestinal tract after oral administration this invention describes a composition containing trans-conchalan microcapsules for modified release of the drug into the gastrointestinal tract. the microcapse core is composed of thetrans-chalcona and polymer used as film coating is the complex polymeric pectin/casein. this polymeric complex is an alternative in the constitution of modified release systems since pectin is a polysaccharide capable of resisting the action of proteases and amylases present in the upper gastrointestinal tractbut may be digested by pectinases present in the colon. In addition, the use of this multi-particulate release system has the highest reproducibility advantage in intestinal transit time relative to the monolithic, as it distributes itself in a more uniform way, minimizing high-concentration drug sites, as well as reducing inter- and intra-individual variation in response the treatment. it could be demonstrated that treatment with trans-chalcona not microencapsulated at the same dose was not sufficient to provide the beneficial effects obtained with the developed prototype, trans-conchala microencapsulated,in the model of acetic acid-induced colitis. In this way, the trans-chalcona when conveyed in the microencapsulated formulation with the polymeric complex provided modified drug release, became sufficient to significantly reduce nf-kb activation and other inflammatory and oxidative stress parameters induced by acetic acid.composição compreendendo trans-chalcona microencapsulada para liberação modificada no trato gastrointestinal após administração por via oral a presente invenção descreve uma composição contendo microcápsulas de trans-chalcona para liberação modificada do fármaco no trato gastrointestinal. o núcleo da microcápsula é composto pela trans-chalcona e o polímero utilizado como filme de revestimento é o complexo polimérico pectina/cas
