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COMPOSE D'AMINE CYCLIQUE
专利权人:
TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人:
YAMAMOTO, SATOSHI,HASUOKA, ATSUSHI
申请号:
CA2617256
公开号:
CA2617256C
申请日:
2006.08.01
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
A compound represented by the formula (I)(see formula I)wherein ring A is a 5- to 8-membered ring optionally havingfurther substituent(s) other than R6, R7 and R8,R1 is an electron-withdrawing group,R2, R3, R4 and R5 are each independently a hydrogen atom, ahalogen atom, a group bonded via a carbon atom, a group bondedvia a nitrogen atom, a group bonded via an oxygen atom or agroup bonded via a sulfur atom,R6 is a halogen atom, a group bonded via a carbon atom, a groupbonded via a nitrogen atom, a group bonded via an oxygen atomor a group bonded via a sulfur atom,R7 is a cyano group, a nitro group, an acyl group optionallyhaving substituent(s), an optionally esterified or amidatedcarboxyl group or a hydrocarbon group optionally havingsubstituent(s), or R6 and R7 optionally form, together with thecarbon atom bonded thereto, a ring optionally havingsubstituent(s), andR8 is a hydrogen atom, a halogen atom, a group bonded via acarbon atom, a group bonded via a nitrogen atom, a groupbonded via an oxygen atom or a group bonded via a sulfur atom,or a salt thereof has a superior action as an androgenreceptor modulator, and is useful for the prophylaxis ortreatment of hypogonadism, male climacteric disorder, frailty,cachexia, osteoporosis and the like.
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