Bonafoux, Dominique,Davis, Heather M.,Frank, Kristine E.,Friedman, Michael M.,Herold, J. Martin,Hoemann, Michael Z.,Huntley, Raymond,Osuma, Augustine,Sheppard, George,Somal, Gagandeep K.,Van Camp, Jen
申请号：
AU2014302365
公开号：
AU2014302365A1
申请日:
2014.06.26
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The invention provides carboxamide compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions, including rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, Crohns disease, inflammatory bowel disease, ulcerative colitis, psoriatic arthritis, psoriasis, ankylosing spondylitis, interstitial cystitis, asthma, systemic lupus erythematosus, lupus nephritis, B cell chronic lymphocytic lymphoma, multiple sclerosis, chronic lymphocytic leukemia, small lymphocytic lymphoma, mantle cell lymphoma, B-cell non-Hodgkins lymphoma, activated B-celllike diffuse large B-cell, lymphoma, multiple myeloma, diffuse large B-celllymphoma, follicular lymphoma, hairy cell leukemia or Lymphoblastic lymphoma.
