BONAFOUX DOMINIQUE,DAVIS HEATHER M,FRANK KRISTINE E,FRIEDMAN MICHAEL M,HEROLD J MARTIN,HOEMANN MICHAEL Z,HUNTLEY RAYMOND,OSUMA Augustine,SHEPPARD George,SOMAL GAGANDEEP K,VAN CAMP JENNIFER,VAN EPPS ST
申请号：
IN201617002560
公开号：
IN201617002560A
申请日:
2016.01.22
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The invention provides carboxamide compounds of Formula (I) pharmaceutically acceptable salts pro drugs biologically active metabolites stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions including rheumatoid arthritis juvenile rheumatoid arthritis osteoarthritis Crohn s disease inflammatory bowel disease ulcerative colitis psoriatic arthritis psoriasis ankylosing spondylitis interstitial cystitis asthma systemic lupus erythematosus lupus nephritis B cell chronic lymphocytic lymphoma multiple sclerosis chronic lymphocytic leukemia small lymphocytic lymphoma mantle cell lymphoma B cell non Hodgkin s lymphoma activated B celllike diffuse large B cell lymphoma multiple myeloma diffuse large B celllymphoma follicular lymphoma hairy cell leukemia or Lymphoblastic lymphoma.
