A combined bioartificial liver support system (1), comprising branch tubes that are connected in sequence: a blood input branch tube (11) for which an upstream tail end is set as a blood input end (111), a first plasma separation branch tube (12) at least comprising a first plasma separator (121), a non-biological purification branch tube (13) at least comprising a plasma perfusion device (131) and a bilirubin adsorber (132), a biological purification branch tube (14) at least comprising a hepatocyte culture tank assembly (141), and a plasma return branch tube (15) for which a downstream tail end is set as a blood output end (151). By means of a three-way device (16), the first plasma separation branch tube (12) is connected to inlet ends of the biological purification branch tube (14) and the non-biological purification branch tube (13), an outlet end of the non-biological purification branch tube (13) is connected to the biological purification branch tube (14), and the outlet end of the non-biological purification branch tube (13) is connected to the plasma return branch tube (15)； the three-way device (16) comprises a three-way joint (161) and branches respectively connected to the three-way joint (161), wherein at least two branches are respectively provided with a flow restricting member and a connecting transfer member.Cette invention concerne un système combiné pour support de foie bioartificiel (1), comprenant des tubes d'embranchement qui sont raccordés en séquence : un tube d'embranchement d'admission de sang (11) dont une extrémité arrière en amont est définie comme extrémité d'admission de sang (111), un premier tube d'embranchement de séparation de plasma (12) comprenant au moins un premier séparateur de plasma (121), un tube d'embranchement de purification non biologique (13) comprenant au moins un dispositif de perfusion de plasma (131) et un adsorbeur de bilirubine (132), un tube d'embranchement de purification biologique (14) comprenant au moins un
